Human Cancer Biology
نویسندگان
چکیده
Purpose:Glioblastomamultiforme (GBM) is an aggressive adult brain tumorwith a poor prognosis.One hallmark of GBM is the accumulation of immunosuppressive and tumor-promoting CD4þFoxP3þGITRþ regulatory T cells (Tregs). Here, we investigated the role of indoleamine 2,3 dioxygenase (IDO) in brain tumors and the impact on Treg recruitment. Experimental Design: To determine the clinical relevance of IDO expression in brain tumors, we first correlated patient survival to the level of IDO expression from resected glioma specimens. We also used novel orthotopic and transgenic models of glioma to study how IDO affects Tregs. The impact of tumorderived and peripheral IDO expression on Treg recruitment, GITR expression, and long-term survival was
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